Casari, Alessandro (2009) Molecular biology and pharmacology of purinergic receptors subtypes. [Laurea triennale]
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Over the last decades it is increased the interest of purinergic receptros as new therapeutic targets. Four projects related to some of there receptors were planned: I) cloning of mouse A e B receptor into the pLXSN vector, expression in CHO cells and pharmacological characterization with cAMP assays; II) expression of human P2Y receptor into human astrocytoma cells and pharmacological characterization; III) removal of a point mutation from the chimeric human P2X 2-3; IV) screening of a series of new compounds at retA1 end A2B receptors with binding assays.
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