Pretto, Francesca (2009) Conjugation of photoactive porphyrins to anti-angiogenic monoclonal antibodies for cancer therapy. [Laurea triennale]
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this thesis exploits different delivery strategy for new porphyrin derivatives using L19, a clinical stage monoclonal antibody, as targeting agent. These novel porphyrin conjugates were deeply characterized with different analytical techniques and proved to be effective either in a in vitro or in an in vivo model.
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