In this Thesis the synthesis, chemical characterization and conformational analysis in solution of two series of peptides containing Cα-tetrasubstituted amino acids that generate an ordered helical structure of great stability, that may be used to calibrate new spectroscopic techniques. These peptides were prepared using total solution synthesis, both “step by step” and “fragment condensation” approach. Conformational analysis in solution (IR and EPR) confirmed that these peptides adopt a helical conformation, primarily 310- helical type. In particular, they will be studied by high frequency (95 GHz) EPR, using PELDOR technique (Prof. Martina Huber, Leiden, The Netherlands).

Peptidi elicoidali rigidi caratterizzati da sonde paramagnetiche per applicazioni spettroscopiche

Busato, Carlo
2010/2011

Abstract

In this Thesis the synthesis, chemical characterization and conformational analysis in solution of two series of peptides containing Cα-tetrasubstituted amino acids that generate an ordered helical structure of great stability, that may be used to calibrate new spectroscopic techniques. These peptides were prepared using total solution synthesis, both “step by step” and “fragment condensation” approach. Conformational analysis in solution (IR and EPR) confirmed that these peptides adopt a helical conformation, primarily 310- helical type. In particular, they will be studied by high frequency (95 GHz) EPR, using PELDOR technique (Prof. Martina Huber, Leiden, The Netherlands).
2010-10
57
TOAC, Amminoacidi C alfa tetrasostituiti, indagini conformazionali, IR, EPR
File in questo prodotto:
File Dimensione Formato  
Tesi_Carlo_Busato.pdf

accesso aperto

Dimensione 1.62 MB
Formato Adobe PDF
1.62 MB Adobe PDF Visualizza/Apri

The text of this website © Università degli studi di Padova. Full Text are published under a non-exclusive license. Metadata are under a CC0 License

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.12608/13907