Dotto, Francesco (2010) Valutazione degli acidi 1,2,6-trimetil-3-idrossi-4-piridincarbossilico e 5-metil-4-idrossi-3-piridincarbossilico come nuovi farmaci chelanti per alluminio e ferro. [Laurea specialistica biennale]
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The therapy for metal overload pathologies involves the administration of suitable cheating agents to selectively remove the metal from the body. A new class of chelating agents has been recently proposed by our research group, the hydroxypyridine carboxylic acids. In this thesis work, we studied the thermodynamic interaction between 4-Hydroxy-5-methyl-3piridincarboxylic acid (DQ5) with Al(III), and between 3-hydroxy-1,2,6-trimethyl -4-pyridine carboxylic acid (DT8126) with Al(III) and Fe(III), by means of potentiometry, UV-VIS, NMR spectroscopy and voltammetry
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