It has a long been known that many, if not all, diseases are associated with changes in the mechanical properties of cells. Although these changes in tissue mechanics have been believed to be a conseguense of the disease, recent data show that alterations of these mechanical properties have a potent effect to many cellular functions. Thus, there is no reason to believe that altered cellular mechanics could be the cause of the disease, rather than its consequence. A complete understanding of cell mechanics and how the latter one depends on the presence of a disease is therefore necessary in order to develop methods of early diagnosis. In this master thesis we report the preliminary results of fibroblast mechanics obtained by simulating, in a numerical context, AFM (Atomic Force Microscopy)
Modellazione numerica della Microscopia a Forza Atomica (AFM) per la stima di parametri da cellule fibroblastiche
Ferrazzi, Giulio
2012/2013
Abstract
It has a long been known that many, if not all, diseases are associated with changes in the mechanical properties of cells. Although these changes in tissue mechanics have been believed to be a conseguense of the disease, recent data show that alterations of these mechanical properties have a potent effect to many cellular functions. Thus, there is no reason to believe that altered cellular mechanics could be the cause of the disease, rather than its consequence. A complete understanding of cell mechanics and how the latter one depends on the presence of a disease is therefore necessary in order to develop methods of early diagnosis. In this master thesis we report the preliminary results of fibroblast mechanics obtained by simulating, in a numerical context, AFM (Atomic Force Microscopy)File | Dimensione | Formato | |
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https://hdl.handle.net/20.500.12608/15508