Zanchetta, Erica (2013) Inibizione dei bromodomini bet con la tieno-triazolo-1,4-diazepina JQ1 e nuovi sviluppi nella contraccezione maschile/ The bet bromodomain inhibition with the thieno-triazolo-1,4-diazepine JQ1 and the development of male contraception. [Laurea specialistica a ciclo unico]
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In vitro and in vivo pre-clinical studies have found that the BET bromodomain inhibition with the thieno-triazolo-1,4-diazepine JQ1 is useful for many diseases, from cancer to HIV. In the specific instance, with the present study of scientific literature we analyse also the possibility of the JQ1 clinical employement as a male contraceptive. Indeed, JQ1 is able to bypass the blood-testis barrier and the molecule impairs spermatogenesis in male mice through the testis-specific bromodomain containing protein (BRDT) inhibition.
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