This work describes the synthesis and the characterization of two analogues of the peptaibiotic Trichogin GA IV, that should explicate an antitumor activity. These peptides contain a residue of the Cα-tetrasubstituted aminoacid Api and the EPR probe TOAC and they were synthesized using the Solid Phase Peptide Synthesis technique. From IR in solution and CD studies, it was determined that the two analogues adopt helical conformations. Tests with artificial cellular membranes demonstrate that the peptides are able to modulate the permeability of the lipid bilayers

Sintesi e studi conformazionali di analoghi del peptaibiotico tricogina GA IV, contenenti Api e TOAC

Fiscato, Marion
2013/2014

Abstract

This work describes the synthesis and the characterization of two analogues of the peptaibiotic Trichogin GA IV, that should explicate an antitumor activity. These peptides contain a residue of the Cα-tetrasubstituted aminoacid Api and the EPR probe TOAC and they were synthesized using the Solid Phase Peptide Synthesis technique. From IR in solution and CD studies, it was determined that the two analogues adopt helical conformations. Tests with artificial cellular membranes demonstrate that the peptides are able to modulate the permeability of the lipid bilayers
2013-10-17
98
Peptaibolic, Aib, 4-aminopiperidine-4-carboxylic acid, membrane lytic activity, antimicrobial peptides.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.12608/17687