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Ceolin, Stefano (2014) Bystander Effects in Photodynamic Therapy of Cancer. [Magistrali biennali]

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Abstract

The aim of this study is to cast new light on the role of NO and Ca2+ in bystander effect propagation during PDT. This work is based on the novel fluorescent probe CuFi and provides the first direct evidence of NO involvement in bystander response during PDT. Moreover, the shape of NO signals suggests a dual mechanism that involves direct release from the target cell as well as enzymatic production. By analyzing our data in the light of simple NO diffusion model, we were able to estimate the contribution of the diffusive component relative to enzymatc production, which amounts to at least 50% of the total NO signals.

Item Type:Magistrali biennali
Uncontrolled Keywords:bystander effects, photodynamic therapy, nitric oxide
Subjects:Area 02 - Scienze fisiche > FIS/07 Fisica applicata (a beni culturali, ambientali, biologia e medicina)
Codice ID:46002
Relatore:Mammano, Fabio
Data della tesi:July 2014
Biblioteca:Polo di Scienze > Dip. Fisica e Astronomia "Galileo Galilei" - Biblioteca
Tipo di fruizione per il documento:on-line per i full-text
Tesi sperimentale (Si) o compilativa (No)?:Yes

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