Domeneghetti , Chiara (2015) Studio della attivitÃ antiproligerativa e antipoisomerica di nuovi composti eteropoliciclici. [Laurea specialistica a ciclo unico]
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The aim of my theis project was to study if 10 new molecules able to inhibit the activity of STAT3. Starting fro the structure of already known inhibitors of STAT3 we focused our attenction on 3 pyridazinone and 7 oxadiazoin derivates. for the molecules antiproliferative properties were evalueted in 3 cancer cell lines. moreover we invastigated their capability to bind DNA and relax supercoiled DNa and their ability to be used as topoisomerase inhibitors.
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