Burra, Silvia (2015) Ruolo del ponte disolfuro nel processo di aggregazione dei VHH. [Laurea specialistica biennale]
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The misfolding of some proteins can lead to the formation of amyloid fibrils, that are insoluble aggregates, which can lead to some neurodegenerative diseases. Some proteins aggregate after the removal of a disulfide bridge. We used nanobodies as model proteins to better understand the role of the SS bridge on the aggregation propensity of lg-G-folded proteins. Proteins without SS bridge form amyloid fibrils when incubated at pH 2 in several denaturant concentrations
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