Single colony bacterial cells communicate with each other on the basis of Quorum Sensing (QS) mechanism, being capable to organize collective behaviour like bioluminescence. In a typical QS mechanism, bacteria provide signal molecules production; above a certain threshold concentration, a consistent fraction of signal molecules binds herselves to receptors on the surface of bacteria, triggering a new phenotype, e.g. bioluminescence, through a cascade of cellular signals. Aim of this thesis is reproducing bioluminescence experimental curves by means of a simplified model; with a suitable combination of deterministic and stochastic algorithms, parameters included in it will be optimized minimizing difference between experimental data and theoretical previsions.
Crescita di colonie batteriche bioluminescenti: ottimizzazione di modelli teorici.
Fanchin, Francesco
2016/2017
Abstract
Single colony bacterial cells communicate with each other on the basis of Quorum Sensing (QS) mechanism, being capable to organize collective behaviour like bioluminescence. In a typical QS mechanism, bacteria provide signal molecules production; above a certain threshold concentration, a consistent fraction of signal molecules binds herselves to receptors on the surface of bacteria, triggering a new phenotype, e.g. bioluminescence, through a cascade of cellular signals. Aim of this thesis is reproducing bioluminescence experimental curves by means of a simplified model; with a suitable combination of deterministic and stochastic algorithms, parameters included in it will be optimized minimizing difference between experimental data and theoretical previsions.File | Dimensione | Formato | |
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https://hdl.handle.net/20.500.12608/28396