Recently two different metabolic phenotypes have been discovered in breast cancer cells. As increasing evidence shows how metabolism is directly connected to cancer invasiveness, it is of interest to identify which enzymes lead to the expression of each phenotype. As first contribution of this work, we present a novel kinetic model that approximates mitochondrial metabolism. Thereafter, we investigate the behviour of the system through multiple numeric simulations

Modelling of mitochondrial metabolism in breast cancer

Zenere, Alberto
2017/2018

Abstract

Recently two different metabolic phenotypes have been discovered in breast cancer cells. As increasing evidence shows how metabolism is directly connected to cancer invasiveness, it is of interest to identify which enzymes lead to the expression of each phenotype. As first contribution of this work, we present a novel kinetic model that approximates mitochondrial metabolism. Thereafter, we investigate the behviour of the system through multiple numeric simulations
2017-02-28
kinetic, modelling, metabolism, breast, cancer
File in questo prodotto:
File Dimensione Formato  
Tesi.pdf

accesso aperto

Dimensione 1.63 MB
Formato Adobe PDF
1.63 MB Adobe PDF Visualizza/Apri

The text of this website © Università degli studi di Padova. Full Text are published under a non-exclusive license. Metadata are under a CC0 License

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.12608/25318