Vai ai contenuti. | Spostati sulla navigazione | Spostati sulla ricerca | Vai al menu | Contatti | Accessibilità

logo del sistema bibliotecario dell'ateneo di padova

Lucca, Camilla (2017) Trattamento combinato di chemioterapia e terapia fotodinamica di cellule tumorali in vitro. [Laurea triennale]

Full text disponibile come:

[img]
Preview
PDF
1029Kb

Abstract

In questa tesi è stato valutato l'effetto del trattamento combinato di terapia fotodinamica (PDT) e chemioterapia in cellule tumorali HeLA derivanti da un adenocarcinoma della cervice uterina; chemioterapico: Docetaxel (DTX) e fotosensibilizzazione: meta-tetra(idrossifenil)clorina (mTHPC). I risultati individuano un'interazione negativa tra i due farmaci quando somministrati contemporaneamente che comporta inibizione del DTX per concentrazioni inferiori a 0.03 μg/ml. Ulteriori esperimenti mostrano tuttavia che l'attività del DTX alla concentrazione di 0.03 μg/ml non risulta alterata se l’mTHPC viene aggiunto alle cellule 4 ore dopo il DTX, suggerendo la necessità di ulteriori studi per la definizione di specifici protocolli di somministrazione dei farmaci considerati.

Item Type:Laurea triennale
Corsi di Laurea Triennale:Scuola di Scienze > Scienze naturali
Uncontrolled Keywords:Chemioterapia, Docetaxel, PDT, mTHPC, Terapie combinate
Subjects:Area 05 - Scienze biologiche > BIO/06 Anatomia comparata e citologia
Codice ID:57518
Relatore:Reddi, Elena
Data della tesi:2017
Biblioteca:Polo di Scienze > CIS "A. Vallisneri" - Biblioteca Biologico Medica
Tipo di fruizione per il documento:on-line per i full-text
Tesi sperimentale (Si) o compilativa (No)?:Yes

Bibliografia

I riferimenti della bibliografia possono essere cercati con Cerca la citazione di AIRE, copiando il titolo dell'articolo (o del libro) e la rivista (se presente) nei campi appositi di "Cerca la Citazione di AIRE".
Le url contenute in alcuni riferimenti sono raggiungibili cliccando sul link alla fine della citazione (Vai!) e tramite Google (Ricerca con Google). Il risultato dipende dalla formattazione della citazione e non da noi.

Agostinis P., Berg K., Cengel K.A. et al. (2011) “Photodynamic therapy of cancer: an update” CA Cancer Journal for Clinicians 61, 250-281. Cerca con Google

Allison R.R., Sibata C.H. (2010) “Oncologic photodynamic therapy photosensitizers: a clinical review” Photodiagnosis and Photodynamic Therapy 7, 61-65. Cerca con Google

Allison R.R. (2014) “Photodynamic therapy: oncologic horizons” Future Oncology 10, 123-142. Cerca con Google

Castano A.P., Demidova T.N., Hamblin M.R. (2004) “Mechanisms in photodynamic therapy: part one-photosensitizers, photochemistry and cellular localization” Photodiagnosis and Photodynamic Therapy 1, 279-293. Cerca con Google

Colin M., Guenard D., Gueritte-Voegelein F. et al. (1989) “Process for the preparation of taxol and 10-deacetyltaxol” Rhone-Poulenc Sante, US Patent 4857653. Cerca con Google

Compagnin C., Baù L., Mognato M. et al. (2009) “The cellular uptake of meta-tetra(hydroxyphenyl)chlorin entrapped in organically modified silica nanoparticles is mediated by serum proteins” Nanotechnology 20, 345101. Cerca con Google

Compagnin C., Moret F., Celotti L. et al. (2011) “Meta-tetra(hydroxyphenyl)chlorin-loaded liposomes sterically stabilised with poly(ethylene glycol) of different length and density: characterisation, in vitro cellular uptake and phototoxicity” Photochemical and Photobiological Sciences 10, 1751-1759. Cerca con Google

Corrie P.G. (2008) “Cytotoxic chemotherapy: clinical aspects” Medicine 36, 24-28. Cerca con Google

Cortes J.E., Pazdur R. (1995) “Docetaxel” Journal of Clinical Oncology 13, 2643-2655. Cerca con Google

Cramers P., Ruevekamp M., Oppelaar H. et al. (2003) “Foscan uptake and tissue distribution in relation to photodynamic efficacy” British Journal of Cancer 88, 283-290. Cerca con Google

Dolmans D.E., Fukumura D., Jain R.K. (2003) “Photodynamic therapy for cancer” Nature Reviews Cancer 3, 380-387. Cerca con Google

Dougherty T.J., Gomer C.J., Henderson B.W. et al. (1998) “Photodynamic therapy” Journal of the National Cancer Institute 90, 889-905. Cerca con Google

Dustin P. (1980) “Microtubules” Scientific American 243, 66-76. Cerca con Google

Gaio E., Scheglmann D., Reddi E. et al. (2016) “Uptake and photo-toxicity of Foscan®, Foslip® and Fospeg® in multicellular tumor spheroids” Journal of Photochemistry and Photobiology B 161, 244-252. Cerca con Google

Gueritte-Voegelein F., Guenard D., Lavelle F. et al. (1991) “Relationships between the structure of taxol analogues and their antimitotic activity” Journal of Medicinal Chemistry 34, 992-998. Cerca con Google

Ho M.Y., Mackey J.R. (2014) “Presentation and management of docetaxel-related adverse effects in patients with breast cancer” Cancer Management and Research 6, 253-259. Cerca con Google

Hong M.J., Cheon Y.K., Lee E.J. et al. (2014) “Long-term outcome of photodynamic therapy with systemic chemotherapy compared to photodynamic therapy alone in patients with advanced hilar cholangiocarcinoma” Gut Liver 8, 318-323. Cerca con Google

Jin M.L., Yang B.Q., Zhang W. et al. (1992) “Combined treatment with photodynamic therapy and chemotherapy for advanced cardiac cancers” Journal of Photochemistry and Photobiology B 12, 101-106. Cerca con Google

Korbelik M. (2009) “Induction of tumor immunity by photodynamic therapy” Journal of Clinical Laser Medicine & Surgery 14, 329-334. Cerca con Google

Krammer B. (2001) “Vascular effects of photodynamic therapy” Anticancer Research 21, 4271-4277. Cerca con Google

Li L., Xie J., Zhang X. et al. (2010) “Retrospective study of photodynamic therapy vs photodynamic therapy combined with chemotherapy and chemotherapy alone on advanced esophageal cancer” Photodiagnosis and Photodynamic Therapy 7, 139-143. Cerca con Google

Luo D., Carter K.A., Miranda D. et al. (2017) “Chemophototherapy: an emerging treatment option for solid tumors” Advanced Science 4, 1600106. Cerca con Google

Maiolino S., Moret F., Conte C. et al. (2015) “Hyaluronan-decorated polymer nanoparticles targeting the CD44 receptor for the combined photo/chemo-therapy of cancer” Nanoscale 7, 5643-5653. Cerca con Google

Master A., Livingston M., Sen Gupta A. (2013) “Photodynamic nanomedicine in the treatment of solid tumors: perspectives and challenges” Journal of Controlled Release 168, 88-102. Cerca con Google

Oniszczuk A., Wojtunik-Kulesza K.A., Oniszczuk T. et al. (2016) “The potential of photodynamic therapy (PDT)-Experimental investigations and clinical use” Biomedicine & Pharmacotherapy 83, 912-929. Cerca con Google

Park D.H., Lee S.S., Park S.E. et al. (2014) “Randomised phase II trial of photodynamic therapy plus oral fluoropyrimidine, S-1, versus photodynamic therapy alone for unresectable hilar cholangiocarcinoma” European Journal of Cancer 50, 1259-1268. Cerca con Google

Petri A., Yova D., Alexandratou E. et al. (2012) “Comparative characterization of the cellular uptake and photodynamic efficiency of Foscan® and Fospeg in a human prostate cancer cell line” Photodiagnosis and Photodynamic Therapy 9, 344-354. Cerca con Google

Postiglione I., Chiaviello A., Palumbo G. (2011) “Enhancing photodynamic therapy efficacy by combination therapy: dated, current and oncoming strategies” Cancers 3, 2597-2629. Cerca con Google

Ringel I., Horwitz S.B. (1991) “Studies with RP 56976 (taxotere): a semisynthetic analogue of taxol” Journal of the National Cancer Institute 83, 288-291. Cerca con Google

Rosa L.P., da Silva F.C. (2005) “Antimicrobial photodynamic therapy: a new therapeutic option to combat infections” Journal of Medical Microbiology and Diagnosis 3, 158. Cerca con Google

Senge M.O. (2011) “mTHPCA drug on its way from second to third generation photosensitizer?” Photodiagnosis and Photodynamic Therapy 9, 170-179. Cerca con Google

Sharman W.M., Allen C.M., van Lier J.E. (1999) “Photodynamic therapeutics: basic principles and clinical applications” Drug Discovery Today 4, 507-517. Cerca con Google

Sibata C.H., Colussi V.C., Oleinick N.L. et al. (2001) “Photodynamic therapy in oncology” Expert Opinion on Pharmacotherapy 2, 917-927. Cerca con Google

Triesscheijn M., Ruevekamp M., Aalders M. et al. (2005) “Outcome of mTHPC mediated photodynamic therapy is primarily determined by the vascular response” Photochemistry and Photobiology 81, 1161-1167. Cerca con Google

Wani M.C., Taylor H.L., Wall M.E. et al. (1971) “Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia” Journal of the American Chemical Society 93, 2325-2327. Cerca con Google

Solo per lo Staff dell Archivio: Modifica questo record