Masutti, Sara (2018) The role of Syndecan-1 in invasion, migration, stemness and radiation sensitivity of triple-negative breast cancer cell lines. [Laurea specialistica a ciclo unico]
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Syndecan-1 (Sdc-1) is a cell-surface heparan sulphate proteoglycan involved in many key events in tumour transformation and progression. Here the focus is on Triple-Negative Breast Cancer (TNBC), an aggressive and extremely heterogeneous subtype of breast cancer. We studied the impact of Sdc-1 knockdown by means of RNA interferences on the genotype and phenotype of four TNBC cell lines, the HCC1806, HCC1937, BT549 and MDAMB468 cell lines, to clarify the role of Sdc-1 in invasion, migration, stemness and radiation sensitivity.
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