Baggio, Chiara (2018) Evaluation of the effect of synthetic polysaccharides in a microcrystal-induced inflammation model. [Laurea specialistica biennale]
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Chronic arthritides is a general term used to define over 150 disorders that are characterized by severe inflammation of the synovium and simultaneously involve adiacent cartilage and bone causing damages abd considerable pain [...]. It as been recently shown that macrophage mannose receptor is implicated in the perpetuation and exacerbation of the inflammation in rheumatic diseases [...]. This lab has recently developed sulfated hydrophilic polymers which selectively target mannose receptor. The aim of the present project was to investigated the efect of this novel polymer in vitro GOUT and pseudoGOUT inflammation model [...]. Results demonstrate that there was a sulphated polymer activity in decreasing the levels of inflammatory cytokine IL-1betha
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