Ceron, Laura (2018) Development and validation of LC-MS methods for the analysis of udp-glucuronosyltransferase (UGT) substrates to support drug-drug interaction studies. [Laurea specialistica biennale]
Per questo documento il full-text online non disponibile.
Dru-drug interactions represent one of the major causes of drug withdrawal from the market. These interactions in fact can cause profound clinical effects either reducing the therapeutic efficacy or enhancing toxicity of a drug, generally modifying drug pharmacokinetics and pharmacodynamics. The anticancer drug erlotinib, for example, inhibits the activity of UGT1A1 responsible for the metabolism of estradiol in betha-estradiol-3-glucoronide, whereas the antimycotics fluconazole inhibits the enzyme UGT2B7 involved in zidovudine metabolism to zidovudine-glucoronide. The development and validation of bioanalytical LC-MS/MS methods for the quantification of the metabolites betha-estradiol-3-glucoronide and zidovudine-glucoronide in human liver microsomal matrix are essential tool for the evaluation of the inhibitory activity of drugs to UGT1A1 and UGT2B7 respectively once drug-drug interacions are performed.
Solo per lo Staff dell Archivio: Modifica questo record